The plague of 1815-17 was not transmitted through human contact, but it certainly took its toll of human life, taking responsibility for the loss of tens of thousands over three years.
“I wish it need not have happened in my time,” said Frodo. “So do I,” said Gandalf, “and so do all who live to see such times. But that is not for them to decide. All we have to decide is what to do with the time that is given us.”